Coronavirus, Ebola and Infectious diseases, Food & Drugs, Studies, Recalls #6

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moomin
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Message 2046526 - Posted: 23 Apr 2020, 15:02:07 UTC - in response to Message 2046521.  

Maybe they do and why not. Many drugs comes from very surprising sources that already can be find in the nature. Like penicillin that was discovered by accident by Alexander Fleming in 1928.
However penicillin "only" kills bacteria, not viruses.
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Message 2046530 - Posted: 23 Apr 2020, 15:16:21 UTC - in response to Message 2046526.  

Maybe they do and why not. Many drugs comes from very surprising sources that already can be find in the nature. Like penicillin that was discovered by accident by Alexander Fleming in 1928.
However penicillin "only" kills bacteria, not viruses.

Nothing strange in using nature for medicines.
Willow bark contains salicin, a compound similar to aspirin.
Digitalis from foxgloves, good for heart conditions even if it is toxic.
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Message 2046558 - Posted: 23 Apr 2020, 17:14:57 UTC

Reports on the wire of Gilead trials of Remdesivir in China were a failure......
Gilead antiviral drug remdesivir flops in first trial
The Financial Times|24 minutes ago
Earlier this month, a study in the New England Journal of Medicine showed early positive results for remdesivir, with 68 per cent of patients improving on the drug. However, the study was not an official trial but rather the collation of data from patients who had been given the drug on a "compassionate use" basis — and was not compared ...
Report of remdesivir flop takes steam out of stocks
Seeking Alpha|7 minutes ago
Citing WHO documents, the FT reports that Gilead's remdesivir has failed in its fist randomized clinical trial.Gilead is saying the WHO post includes "inappropriate characterizations of the study.

....So if Hydroxychloroquine is not the answer.......

Note: this is a very early trial and needs further corroboration along with the many trials of the combination of both therapies. This is just a stopgap measure to save those already in jeopardy. A true rna anti-vaccine still needs to be developed, thoroughly tested, and deployed worldwide before we're out of the woods.

"Sour Grapes make a bitter Whine." <(0)>
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Message 2046575 - Posted: 23 Apr 2020, 20:03:22 UTC - in response to Message 2046558.  

Note: this is a very early trial and needs further corroboration along with the many trials of the combination of both therapies. This is just a stopgap measure to save those already in jeopardy. A true rna anti-vaccine still needs to be developed, thoroughly tested, and deployed worldwide before we're out of the woods.
Yes. It will take at least one year to develop a COVID-19 vaccine as scientists believe. Prophylaxis maybe will be found earlier than that. Who knows? Not even WHO knows. As for me I think we are seeing that the spreading of the corona virus is catching down for now for what ever the reasons.
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Message 2046632 - Posted: 23 Apr 2020, 23:09:30 UTC
Last modified: 23 Apr 2020, 23:10:58 UTC

One of the "comorbidities":...

(Or how to suffer more likely dying sooner)


Areas With More Air Pollution Have Had More Covid-19 Fatalities
wrote:
... research shows that exposure to air pollution may be “one of the most important contributors to fatality” caused by covid-19...



The US Cities With the Worst Air Pollution All Have Something in Common
wrote:
... research from the American Lung Association reveals which parts of the U.S. have the most polluted air.

In their 21st annual “State of the Air” report for 2020, released Tuesday, the group examined federal data on the two most widespread types of air pollution to create a comprehensive overview of toxic air across the country. The report found that that cities in the West, especially in California, face a disproportionate amount of health-harming emissions and that half of Americans are breathing dangerous air...

... These pollutants can cause a variety of respiratory and pulmonary issues, strokes, and other health problems...




So... What is happening with the EPA?...

All in the USA...

All in our deadly greedy world,
Martin
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Message 2046635 - Posted: 23 Apr 2020, 23:12:49 UTC

So... What is happening with the EPA?...
Trump. :-(
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Message 2046650 - Posted: 24 Apr 2020, 0:08:40 UTC - in response to Message 2046632.  

One of the "comorbidities":...

(Or how to suffer more likely dying sooner)


Areas With More Air Pollution Have Had More Covid-19 Fatalities
wrote:
... research shows that exposure to air pollution may be “one of the most important contributors to fatality” caused by covid-19...



The US Cities With the Worst Air Pollution All Have Something in Common
wrote:
... research from the American Lung Association reveals which parts of the U.S. have the most polluted air.

In their 21st annual “State of the Air” report for 2020, released Tuesday, the group examined federal data on the two most widespread types of air pollution to create a comprehensive overview of toxic air across the country. The report found that that cities in the West, especially in California, face a disproportionate amount of health-harming emissions and that half of Americans are breathing dangerous air...

... These pollutants can cause a variety of respiratory and pulmonary issues, strokes, and other health problems...




So... What is happening with the EPA?...

All in the USA...

All in our deadly greedy world,
Martin


Just another mitigating factor in the disease but it begs the question why isn't Los Angeles and the burbs as big a hot spot as New York City? I think the difference may be what causes the air pollution....cars. Everybody in LA drives everywhere one or two occupants to a vehicle. in NYC they crowd into the subways like cattle in a livestock freight car.

https://reason.com/2020/04/23/what-explains-the-difference-between-estimated-covid-19-fatality-rates-in-new-york-and-california/
The current crude case fatality rate (CFR) in New York City—confirmed deaths as a share of confirmed cases—is more than 7 percent. If you include "probable deaths"—cases where infection was not confirmed by virus tests but suspected based on symptoms and circumstances—the crude CFR rises to nearly 11 percent. By comparison, the national average is currently 5.7 percent.

That average disguises wide geographic variation. In Texas, where I live, the current crude CFR is 2.6 percent. It is 1.5 percent in Wyoming, 3.3 percent in Florida, 3.9 percent in California, 5.4 percent in New Jersey, and 6.2 percent in Louisiana.

...New York City's experience with COVID-19 could mean that the IFR estimates from the California studies are wildly off. It also could mean that a much larger share of the population is infected in New York City, as Cuomo's numbers suggest, and that people with the disease tend to do worse there for reasons that may include an overburdened health care system. Or all three of those things could be true to some extent. We won't have a clearer answer until additional research sheds light on the actual prevalence of the virus in different parts of the country.


"Sour Grapes make a bitter Whine." <(0)>
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Message 2046661 - Posted: 24 Apr 2020, 1:08:43 UTC - in response to Message 2046650.  

Just another mitigating factor in the disease but it begs the question why isn't Los Angeles and the burbs as big a hot spot as New York City? I think the difference may be what causes the air pollution....cars. Everybody in LA drives everywhere one or two occupants to a vehicle. in NYC they crowd into the subways like cattle in a livestock freight car.
Of course it's a factor. There are a lot more social distancing in LA then in NY. Cars, public transportation all different. It's the very same here in Sweden. It's Stockholm and some counties around it that are suffering the most. Otherwise not.
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Message 2046664 - Posted: 24 Apr 2020, 1:47:36 UTC - in response to Message 2046650.  
Last modified: 24 Apr 2020, 1:49:51 UTC

One of the "comorbidities":...

(Or how to suffer more likely dying sooner)


Areas With More Air Pollution Have Had More Covid-19 Fatalities
wrote:
... research shows that exposure to air pollution may be “one of the most important contributors to fatality” caused by covid-19...



The US Cities With the Worst Air Pollution All Have Something in Common
wrote:
... research from the American Lung Association reveals which parts of the U.S. have the most polluted air.

In their 21st annual “State of the Air” report for 2020, released Tuesday, the group examined federal data on the two most widespread types of air pollution to create a comprehensive overview of toxic air across the country. The report found that that cities in the West, especially in California, face a disproportionate amount of health-harming emissions and that half of Americans are breathing dangerous air...

... These pollutants can cause a variety of respiratory and pulmonary issues, strokes, and other health problems...




So... What is happening with the EPA?...

All in the USA...

All in our deadly greedy world,
Martin


Just another mitigating factor in the disease but it begs the question why isn't Los Angeles and the burbs as big a hot spot as New York City? I think the difference may be what causes the air pollution....cars. Everybody in LA drives everywhere one or two occupants to a vehicle. in NYC they crowd into the subways like cattle in a livestock freight car.

https://reason.com/2020/04/23/what-explains-the-difference-between-estimated-covid-19-fatality-rates-in-new-york-and-california/
The current crude case fatality rate (CFR) in New York City—confirmed deaths as a share of confirmed cases—is more than 7 percent. If you include "probable deaths"—cases where infection was not confirmed by virus tests but suspected based on symptoms and circumstances—the crude CFR rises to nearly 11 percent. By comparison, the national average is currently 5.7 percent.

That average disguises wide geographic variation. In Texas, where I live, the current crude CFR is 2.6 percent. It is 1.5 percent in Wyoming, 3.3 percent in Florida, 3.9 percent in California, 5.4 percent in New Jersey, and 6.2 percent in Louisiana.

...New York City's experience with COVID-19 could mean that the IFR estimates from the California studies are wildly off. It also could mean that a much larger share of the population is infected in New York City, as Cuomo's numbers suggest, and that people with the disease tend to do worse there for reasons that may include an overburdened health care system. Or all three of those things could be true to some extent. We won't have a clearer answer until additional research sheds light on the actual prevalence of the virus in different parts of the country.

You are a couple of decades behind on Los Angeles and smog. Until King Donald said CARB (California Air Resources Board) could not require cleaner cars, Los Angeles air was nearing the top of the cleanest big cities. It long ago ceased being the dirtiest. When I was a young'n in LA you had to be careful to not try to suck in a full lung of air, or it burned as bad as a heart attack. Last couple decades breath as deep as you want, no issue. It is one of the best environmental success stories on the planet with the clean cars, never mind the replacement of old aging coal fire electric plants with natural gas, the near total elimination of hydrocarbon emissions from the several large oil refineries in the Los Angeles Basin, the ending of trash incineration, and the very many other changes put in place by CARB and SCAQMD (South Coast Air Quality Management District) in the decades. It is worth every penny.

But, Pasadena/Glendale and Long Beach both have huge numbers. Pasadena/Glendale is at the north end of the basin, next to some of the highest ridge lines and as such suffer the brunt of the dirty air generated from the entire basin, when onshore winds blow, and they do for most of the year, LA's natural air conditioner. Now why Long Beach at the ocean side? Huge container port - ports of Los Angeles/Long Beach are the busiest container ports, scads of diesel truck engines at idle for hours at a time waiting for an ocean going multi-modal container to be put on the chassis. Every ship in port running their ships engines to generate electricity for the ship, flags from all over the third world, so their engines have no pollution control, so the local generated smog hits. Now you have some true local knowledge.

As to NY vs. CA you are likely right, cars vs. petri dish subway cars. Saw a meme, "if you are close enough to smell my fart, you are too close for social distance." I think that pretty well sums up the situation on a subway car. One person sick gets on and by the next stop nearly everyone will have it. Data I've seen for NY shows almost all cases in the NYC area and upstate as minimal.

Some people only process visually https://www.youtube.com/watch?v=wJ2NMD3VWio
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Message 2046734 - Posted: 24 Apr 2020, 13:34:56 UTC

France limits sale of nicotine products after coronavirus research
https://www.thelocal.fr/20200424/france-limits-sale-of-nicotine-products-after-coronavirus-research?fbclid=IwAR2_ypUOIjBW8qo6zbuBvAd2POI8UDhxFkPlahwUiU4DLLkgaKvqy8Nl7GM


.....well that didn't take long........

"Sour Grapes make a bitter Whine." <(0)>
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Message 2046745 - Posted: 24 Apr 2020, 14:36:06 UTC - in response to Message 2046734.  

I hope Trump bans the sale of disinfectant after his irresponsible (dangerous) remarks about injecting it yesterday.
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Message 2046762 - Posted: 24 Apr 2020, 15:50:07 UTC - in response to Message 2046745.  

I hope Trump bans the sale of disinfectant after his irresponsible (dangerous) remarks about injecting it yesterday.

Bleach works in the gene pool just as well as tide pods..........

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Message 2046771 - Posted: 24 Apr 2020, 16:22:48 UTC - in response to Message 2046748.  

I hope Trump bans the sale of disinfectant after his irresponsible (dangerous) remarks about injecting it yesterday.

He's obviously totally insane (if anyone ever doubted that).
Even a 5 year old, knows that household disinfectants are dangerous to ingest, and of course lethal to inject into the body.

Trump's deadly dangerous comments about disinfectants and light and heat are beyond incredible.

I'm in disbelief.

He really must be senile and desperate. Or simply senile and unaware or uncaring. His senile "you-know-what" comment whilst pointing to his head also suggests that he knows for himself that he is lost for words...

As for the official that lead up to Trump trumping up such deadly ridiculousness... Phew, what an invidious position to suffer! I guess no one could have guessed that such craziness could ensue!


First an antimalarial drug was taken 'out of context'. Now disinfectants!

What Trump-ism next?!

And how many more of the population are (fatally) misdirected by 'as-seen-on-TV' Trump?

There has to be a law against such fatal incitement and dangerous recklessness.

The consequences of those Trump comments are clearly not in the public good.

Incredible.


Only in the USA?
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Message 2046776 - Posted: 24 Apr 2020, 16:54:06 UTC - in response to Message 2046762.  

I hope Trump bans the sale of disinfectant after his irresponsible (dangerous) remarks about injecting it yesterday.

Bleach works in the gene pool just as well as tide pods..........

Unfortunately the average science IQ of a MAGA hat wearer does not know that.

Every distributor of those products has had to issue statements to not follow King Donald's orders because they will get lawsuits from the families of the Darwin award winners who believe in King Donald.
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Message 2046782 - Posted: 24 Apr 2020, 17:58:05 UTC - in response to Message 2046771.  

Trump's deadly dangerous comments about disinfectants and light and heat are beyond incredible.

I'm in disbelief...

... There has to be a law against such fatal incitement and dangerous recklessness.

The consequences of those Trump comments are clearly not in the public good.

Incredible.


Further comment taken over to the Trump thread (Message 2046780) to avoid polluting this thread...


Only in the USA?
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Message 2046784 - Posted: 24 Apr 2020, 18:03:43 UTC

Long Beach


Back in '73, I was on dA Intrastate going to Long Beach from Compton. 'Bout 6 AM.

Traffic was SuperHeavy.

My Eyes Watering like a mO fO and I was Gagging.

Man O Live. Da FUMEs were HORRIFIC.

Dat was dA WORSE I've Ever Experienced.

However. Most any other time I've driven da HiWays and BiWays of KALI, back then, Breathing was Basically 'NOrmal'. A Basic Meh.

Dat Morning Must of Been 'Special'.

GOoD to be RUBE

Yep


May we All have a METAMORPHOSIS. REASON. GOoD JUDGEMENT and LOVE and ORDER!!!!!
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Message 2046801 - Posted: 24 Apr 2020, 20:17:35 UTC

Shocking news from Sweden. Vectors gathering in the parks!
Photo from a couple hours ago
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Message 2046802 - Posted: 24 Apr 2020, 20:18:25 UTC - in response to Message 2046784.  

Long Beach


Back in '73, I was on dA Intrastate going to Long Beach from Compton. 'Bout 6 AM.

Traffic was SuperHeavy.

My Eyes Watering like a mO fO and I was Gagging.

Man O Live. Da FUMEs were HORRIFIC.

Dat was dA WORSE I've Ever Experienced.

Yep, '73 was bad.
A little history ...

Good summary of health effects, and history of control, and some bad episodes worldwide. Really should read the health section and think about how it would apply Covid-19
https://www.aqmd.gov/home/research/publications/smog-and-health-historical-info
The symptoms are familiar to all those who live in cities where the air is polluted: aching lungs, wheezing, coughing, headache. Millions of residents of the South Coast Basin (which includes Los Angeles, Orange, and parts of San Bernardino and Riverside counties) breathe dirty air some one-third the days of the year.


A reminder that sounds a lot like a Covid Stay at home from back in the '70's
https://www.latimes.com/local/lanow/la-me-ln-obama-smog-20150803-htmlstory.html
If a Stage 3 alert had been predicted, the article said, "all commercial and industrial establishments would have been required to close down, as on a national holiday, and all motorists would have been requested to leave the highways."


A article from 2015 on how much better it is noting then it has been a decade since the last smog alert had been issued, add another five years to today.
https://www.reuters.com/article/us-usa-california-pollution/drought-warm-weather-bring-smog-day-memories-in-california-idUSKBN0MN16U20150327
Years of tight environmental rules improved California air quality so much that the state has not issued a smog alert in a dozen years.

To be sure, California air remains much cleaner today than in 1975, when authorities issued 120 Stage 1 smog alerts that warned the elderly and young children they might have trouble breathing, and urged people with heart and respiratory problems to stay inside.

The state’s last Stage 1 alert was issued in 2003, and California has not had a stage 3 alert - the worst - since 1974.
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Message 2046804 - Posted: 24 Apr 2020, 20:32:28 UTC

No worries, there'll always be more immigrant/migrant workers needing a job, our profits are safe.
Untold story of America's biggest outbreak
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Message 2046812 - Posted: 24 Apr 2020, 21:24:58 UTC

Canada rejects 1 million ‘non-compliant’ masks from China
By Joshua Rhett Miller
April 24, 2020
https://nypost.com/2020/04/24/canada-rejects-one-million-non-compliant-masks-from-china/

Like you say, "all in our one greedy world".

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Message boards : Politics : Coronavirus, Ebola and Infectious diseases, Food & Drugs, Studies, Recalls #6


 
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