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Wiggo

Send message Joined: 24 Jan 00 Posts: 37327 Credit: 261,360,520 RAC: 489
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There maybe some light at the end of this insidious tunnel.
Alzheimer's Development as Cellular Cleaners Offer Hope for New Treatments.
Scientists may have uncovered a new mechanism for treating Alzheimer's disease, offering hope to millions of patients worldwide.
The discovery involves the activation of the brain's cellular clean-up crew, resulting in improvements in memory and cognitive function in mouse models......
.....Today, there is no known cure for Alzheimer's, although scientists believe that it is caused by the abnormal buildup of proteins in and around the brain cells. In the past, scientists observed that special immune cells in the brain called astrocytes became activated in response to these protein clumps. But the mechanisms by which the astrocytes are able to remove the protein clumps are not well understood.
Now, scientists from the Korea Institute of Science and Technology, along with the Institute for Basic Science and Boston University, have shown that the presence of these protein clumps activates cellular recycling pathways in these cells, turning them into protein clearing machines.
The transformation appears to be mediated by temporarily switching on specific genes involved in this recycling process. Therefore, the research team hypothesized that if we were able to artificially induce this transformation, we might be able to facilitate the removal of these protein clumps in the brains of Alzheimer's patients.
To explore this further, the team used a group of genetically engineered mice that have been designed to model Alzheimer's disease. They found that, by activating these recycling genes, the damaged neurons in the mice's brains began to recover, resulting in improved memory and cognitive functions.
Meanwhile, inhibiting these genes showed a significant worsening of Alzheimer's symptoms, including an increased build-up of these protein clumps and subsequent neuronal damage.
More work needs to be done to confirm these results in humans, but the study offers new insights into the protective mechanisms used by our brains to ward off neurodegenerative disorders, and proposes a potential new therapeutic target for future drug development....
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ML1 Volunteer moderator Volunteer tester
Send message Joined: 25 Nov 01 Posts: 21541 Credit: 7,508,002 RAC: 20
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Not a good read:
Unleashed by Boris Johnson review – memoirs of a clown
wrote:All the fancy verbiage in the world cannot disguise the emptiness at the heart of this self-serving, solipsistic book...
... But Boris Johnson does not do reflective. He never has and he never will. And nor does his new memoir, with its unnerving title...
... if it is heart-searching and confessions you seek from the pen of Britain’s most iconoclastic prime minister, you can stop now...
... describing how Johnson felt in April 2020 when he had to be transferred from Downing Street to St Thomas’ hospital suffering from Covid: "It wasn’t just the physical distress; it was the guilt, the political embarrassment of it all..."
... There’s a lot worth parsing there. And plenty that is characteristic of Johnson’s writing more generally ... then there’s also the sheer dishonesty and the lies. In reality, Johnson was a chronically indecisive prime minister, emphatically not one who led from the front ... His solipsistic admission that he thought going into hospital was an embarrassing look for a leader shows where his instinctive priorities lay...
... Yet listen to the Covid inquiry, and the evidence of what things were really like at the heart of Johnson’s government in 2020 is jaw-dropping. “I’ve never seen a bunch of people less well equipped to run a country,” said the cabinet secretary...
Indeed: "He is not going to change."
In my most humble opinion:
Deadly buffoonery at the highest.
Stay safe folks?
Martin
See new freedom: Mageia Linux
Take a look for yourself: Linux Format
The Future is what We all make IT (GPLv3)
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Wiggo

Send message Joined: 24 Jan 00 Posts: 37327 Credit: 261,360,520 RAC: 489
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Will the venom of our most deadliest spider really help? Researchers intend to find out.
World-first Aussie research using funnel-web venom molecule to treat heart attacks.
World-first Australian research is using funnel-web spider venom to protect the heart during heart attacks.
The University of Queensland researchers have on Sunday been granted $17m of government money to run clinical trials.
Project leader Glenn King says the drug, which mimics the venom, has the potential to save thousands of lives each year and “drastically improve” the quality of life for heart attack survivors.
Seven-thousand Australians die of a heart attack each year, and in total 55,000 have an attack annually. Heart attacks are the leading cause of death globally.
The researchers discovered a peptide which protects the heart during a heart, and also improves the viability of a donor heart.
Funnel-webs have the Hi1a peptide as protection from predators, but in humans, the peptide stops heart and brain cells from dying. In this research the spider peptide is synthesised in a lab.
The drug has already been shown effective in treating stroke. On Sunday the Federal Health Minister announced the government was granting $17.8m over five years for development.........
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ML1 Volunteer moderator Volunteer tester
Send message Joined: 25 Nov 01 Posts: 21541 Credit: 7,508,002 RAC: 20
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More of the Unleashed of Boris Johnson:
‘I felt like Achilles in a hard hat’: an extract from Boris Johnson’s ‘alternative’ memoir
wrote:Unleashed, the former PM’s account of his days in office, is published today. But other versions of the truth are also available …
When it was announced that Boris Johnson was to publish an honest account of his time in Downing Street, we all thought: how honest would it be?...
... No. He has characteristically omitted from his book...
... with an even more honest appraisal of those Big Dog Days. In a companion, so-called “parody” volume to his own brilliant memoir, I present his life as a series of useful life lessons: If It Ain’t Fixed, Break It; A Lie Isn’t A Lie If It’s A Joke, etc.
But I have also corrected the public perception of events which culminated in his being forced out by what he courageously called a “media-driven hoo-hah”. The Guardian has selected some uncontroversial extracts from that ultra-honest timeline, below …
Ouch!
How do we let such politicians in to play such (deadly) 'games' with our lives?...
Only in the UK?
Martin
See new freedom: Mageia Linux
Take a look for yourself: Linux Format
The Future is what We all make IT (GPLv3)
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Wiggo

Send message Joined: 24 Jan 00 Posts: 37327 Credit: 261,360,520 RAC: 489
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There's hope for a better vaccine.
Australia’s first mRNA Covid vaccine candidate could solve ‘immune imprinting’ problem.
Researchers developing Australia’s first mRNA Covid vaccine say they may have solved the “immune imprinting” issue that has contributed to the declining effectiveness of boosters as the virus mutates.
Immune imprinting, also known as original antigenic sin, occurs when the body’s original immune response to a virus — either from vaccination or infection — becomes less effective against new variants of the same virus.
The Australian-based vaccine candidate, being developed by the Monash Institute of Pharmaceutical Sciences (MIPS) in collaboration with the Doherty Institute, aims to tackle the problem by encoding the proteins on the surface of the receptor-binding domain — the tip of the virus ‘spike’.
In a preclinical study, published in Molecular Therapy Methods and Clinical Development, the researchers tested their mRNA ‘membrane-anchored receptor-binding domain’ (mRNA RBD-TM) vaccine against ancestral Covid vaccines by comparing third-dose immune responses to Omicron variants in mice.......
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Dr Who Fan Volunteer tester

Send message Joined: 8 Jan 01 Posts: 3386 Credit: 715,342 RAC: 4
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Avery, a singer with a substantial social media following, said in a recent video that Ozempic gave her a bone-thinning disease after taking the weight loss drug for one year.
averyofficial
Breaking down the history of my ED in depth so people can better understand how things like this happen I’m spreading awareness because these medications have now become WAY too available - they are sold at plastic surgery offices, med spas, and online websites where you can just lie about your weight to get it. Because of this, many people with body dismorphia are getting this medication to drop weight way quicker than is natural - and it comes with consequences!!! Please do your research, and ask yourself if it is really worth the long term side effects. It was not worth it for me. #greenscreen #ozempic #edawareness #osteoporosis #eatingdisorder
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