Ebola and Infectious diseases Part Two

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Profile Julie
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Message 1590262 - Posted: 22 Oct 2014, 18:14:00 UTC - in response to Message 1590193.  
Last modified: 22 Oct 2014, 18:16:00 UTC

@297902: found it:

http://www.express.co.uk/news/world/519342/Ebola-USA-Dallas-Homeless-Man-Panic-Thomas-Duncan-ZMapp-Supplies

Of the seven people who have been treated with ZMapp, only two have died.


That makes a survival percentage of what, 86% (my math isn't that good, correct me if I'm wrong)

Thing is, they shouldn't have ran out in the first place, a lot of casualties would have been saved then.

5 out of 7 is a survival rate of 71.4%
http://www.who.int/mediacentre/factsheets/fs103/en/
According to the above link
The average EVD case fatality rate is around 50%. Case fatality rates have varied from 25% to 90% in past outbreaks.


so in some past outbreak the survival rate may have been higher than the rate attributed to ZMapp in this outbreak.
Not much point in stockpiling experimental drugs.
Hopefully ZMapp is a magic bullet, but the evidence for that still doesn't exist.



Thanx for the correction, my math stinks:)

They haven't been using the serum long enough on humans to be able to calculate a representative survival rate imo.
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Message 1590297 - Posted: 22 Oct 2014, 19:28:28 UTC

I LAUGH In The Face of OEbola. Infect Me. HA! I'm made of STONE! HA! HA!! Besides, if I Could Get 'it', How would you Find A Vein? HA HA and HA!

HO HUM. Beat Dat Infect Me if You Can DRum.

Hey, If You Get OEbola in Da Forest, like me, Would Anybody Know? NO THEY WOULDN'T. I WOULD DIE, UGLY and ALONE! HA! To You HO HUM! HA!

I SCREAM and No One Hears.

You Guys Are Frakkin' Funny. OEbola Worm is ROTSLIMELMAO!

Keep Cracking Me Up and I Might Not Go Away. heeeheeehee

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May we All have a METAMORPHOSIS. REASON. GOoD JUDGEMENT and LOVE and ORDER!!!!!
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Message 1590300 - Posted: 22 Oct 2014, 19:32:43 UTC

Ok then:)
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Message 1590324 - Posted: 22 Oct 2014, 19:59:27 UTC - in response to Message 1590319.  

BEN you may have a chronic case of Schadenfreude.
I've heard it can be deadly.


LOL!!!
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Message 1590326 - Posted: 22 Oct 2014, 20:02:15 UTC - in response to Message 1590319.  

BEN you may have a chronic case of Schadenfreude.
I've heard it can be deadly.

probably the result of being on the "pot" too long.
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Message 1590331 - Posted: 22 Oct 2014, 20:16:19 UTC - in response to Message 1590326.  

BEN you may have a chronic case of Schadenfreude.
I've heard it can be deadly.

probably the result of being on the "pot" too long.


No more potty training for BEN...
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Message 1590357 - Posted: 22 Oct 2014, 20:40:50 UTC

OK, I'm PPE'ed Up to Stop OEbola. Next Disease Please.

Did I 'hit' the pot or Did The 'Pot' hit me.

ROTFLMAO. I'm SOOOOOOOOOOOOOOOOOO Lucid and Profundity Like.

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Message 1590410 - Posted: 22 Oct 2014, 22:09:34 UTC - in response to Message 1590393.  

Did I 'hit' the pot or Did The 'Pot' hit me.

ROTFLMAO. I'm SOOOOOOOOOOOOOOOOOO Lucid and Profundity Like.' '

WEll BEN we'ze a both nowin the serius guy s'always plainin bout da pot causen he wants to but kant cause o da trukkin thingy.

You "potheads" do what you want. By that very same token, I do not only what I want, but what is legal. Dopeheads & P***heads while under the influence should not be allowed on the roads.

I'd much rather cuddle up with a lovely girl than watch sad people dope up because they can't handle the stress of life...

...a nice soft cuddly girl is much more fun :-)
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Message 1590439 - Posted: 22 Oct 2014, 23:51:28 UTC - in response to Message 1590410.  

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Message 1590443 - Posted: 22 Oct 2014, 23:57:30 UTC - in response to Message 1590439.  

Nurse Who Contracted Ebola Virus-Free, Mom Says


Nurse Amber Vinson's Blood Tests Negative for Ebola

A Dallas nurse who is being treated for the deadly Ebola virus got some good news Wednesday, when blood tests returned negative for the virus that has killed more than 4,800 people worldwide in seven months.

The test results don’t mean that Amber Vinson, 29, is leaving Emory University Hospital in Atlanta anytime soon, or that she is Ebola-free, a source with knowledge of her case told NBC News. But it does mean Vinson will be moved to a lower-risk section of the isolation unit.

http://www.nbcnews.com/storyline/ebola-virus-outbreak/nurse-amber-vinsons-blood-tests-negative-ebola-n231986


Nurse Who Contracted Ebola Virus-Free, Mom Says

A Dallas nurse who contracted Ebola from Liberian national Thomas Duncan is virus-free, her mother told ABC News in a statement.

Amber Vinson became the second person to contract Ebola in the United States after she treated Duncan at Texas Health Presbyterian Hospital in Dallas. Duncan died of the virus on Oct. 8, and Vinson's fellow nurse, Nina Pham, 26, tested positive for Ebola on Oct. 11.

http://abcnews.go.com/Health/nurse-contracted-ebola-virus-free-mom/story?id=26385928





Amber Vinson’s family says she is Ebola-free, but Emory and CDC officials have yet to confirm statement

http://thescoopblog.dallasnews.com/2014/10/amber-vinsons-family-says-she-is-ebola-free-but-emory-officials-have-yet-to-confirm-statement.html/
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Message 1590445 - Posted: 22 Oct 2014, 23:57:38 UTC - in response to Message 1590439.  
Last modified: 23 Oct 2014, 0:00:34 UTC

Ebola Today: 322 Have Died in Five Days; Nurse’s Dog Tests Negative for Ebola


I hope they haven't already put the dog down then.

2100 a week + scary ..
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Message 1590453 - Posted: 23 Oct 2014, 0:04:08 UTC - in response to Message 1590445.  

Ebola Today: 322 Have Died in Five Days; Nurse’s Dog Tests Negative for Ebola


I hope they haven't already put the dog down then.

2100 a week + scary ..


The Dog, was Negative for Ebola
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Message 1590458 - Posted: 23 Oct 2014, 0:06:04 UTC - in response to Message 1590453.  

WASHINGTON -- Ron Klain steps up to his new role as Ebola czar Wednesday morning. Here's a glimpse at what his role as the President's Ebola czar will and won't entail, according to sources inside and outside the White House.

Don't expect to see Klain briefing the public on the contours of the Ebola response. That will be left to Tom Frieden, head of the Centers for Disease Control (CDC), Allergy and Infectious Disease Director Anthony Fauci and relevant cabinet officials, as required.

http://www.cbsnews.com/news/what-to-know-about-ron-klains-job-as-ebola-czar/

I hope he does not open his mouth.
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Message 1590462 - Posted: 23 Oct 2014, 0:10:09 UTC - in response to Message 1590458.  

Glenn, better link on the dog.

Spaniel belonging to Ebola-infected nurse tests negative

DALLAS - A dog belonging to Dallas nurse Nina Pham has so far tested negative for Ebola. City officials say the one-year-old dog named Bentley will be tested again before his quarantine period ends November 1st. Pham is in good condition at the National Institutes of Health in Maryland.

http://www.cbsnews.com/news/spaniel-belonging-to-ebola-infected-nurse-cleared/
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Message 1590464 - Posted: 23 Oct 2014, 0:11:14 UTC - in response to Message 1590410.  

I'd much rather cuddle up with a lovely girl than watch sad people dope up because they can't handle the stress of life...

...a nice soft cuddly girl is much more fun :-)

Sirus they are not mutually exclusive.
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Message 1590481 - Posted: 23 Oct 2014, 1:28:27 UTC - in response to Message 1590464.  

Official WHO Ebola toll near 5,000 with true number nearer 15,000

(Reuters) - At least 4,877 people have died in the world's worst recorded outbreak of Ebola, and at least 9,936 cases of the disease had been recorded as of Oct. 19, the World Health Organization (WHO) said on Wednesday, but the true toll may be three times as much.

The WHO has said real numbers of cases are believed to be much higher than reported: by a factor of 1.5 in Guinea, 2 in Sierra Leone and 2.5 in Liberia, while the death rate is thought to be about 70 percent of all cases. That would suggest a toll of almost 15,000.

http://www.reuters.com/article/2014/10/22/us-health-ebola-who-idUSKCN0IB23220141022

I hope those #'s are wrong.
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Message 1590516 - Posted: 23 Oct 2014, 3:07:17 UTC

All Knowing said:
I'd much rather cuddle up with a lovely girl than watch sad people dope up because they can't handle the stress of life...


Sorry Not Me. Not Dr. HO HUM. As A BigAss Piece of Lava, I Prefer to Cuddle Up wif A Nice Big Lumpy Hunk of Granite. Sadly, No Go Here, and Thus Lonely Days, Lonely Nights, where would I Be wifout My Drum Drum.

HO HUM. Bangin' On dA Best Izzz Can. Oh, Please Don't HateMe 'cause I'm Irritating. Please? Thanks. You Beez Sweetness Personified.

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May we All have a METAMORPHOSIS. REASON. GOoD JUDGEMENT and LOVE and ORDER!!!!!
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Message 1590998 - Posted: 23 Oct 2014, 21:59:49 UTC

You all are gonna love this... Its behind a paywall, so i'll copy-paste as much as I can...

http://www.nytimes.com/2014/10/24/health/without-lucrative-market-potential-ebola-vaccine-was-shelved-for-years.html?hp&action=click&pgtype=Homepage&version=LedeSum&module=first-column-region&region=top-news&WT.nav=top-news&_r=0&gwh=3E4FC30FAD8A3243C63A3CA2DBA94BEC&gwt=pay&assetType=nyt_now

GALVESTON, Tex. — Almost a decade ago, scientists from Canada and the United States reported that they had created a vaccine that was 100 percent effective in protecting monkeys against the Ebola virus. The results were published in a respected journal, and health officials called them exciting. The researchers said tests in people might start within two years, and a product could potentially be ready for licensing by 2010 or 2011.

It never happened. The vaccine sat on a shelf. Only now, with nearly 5,000 people dead from Ebola and an epidemic raging out of control in West Africa, is the vaccine undergoing the most basic safety tests in humans.

Its development stalled in part because Ebola was rare, and until now outbreaks had infected only a few hundred people at a time. But experts also acknowledge that the lack of follow-up on such a promising candidate reflects a broader failure to produce medicines and vaccines for diseases that afflict poor countries. Most drug companies have resisted spending the enormous sums needed to to develop products useful mostly to poor countries with little ability to pay for them.

Now, as the growing epidemic devastates West Africa and is seen as a potential threat to other regions as well, governments and aid groups have begun to open their wallets. A flurry of research to test drugs and vaccines is underway, with clinical trials starting for several candidates, including the vaccine produced nearly a decade ago. With no vaccines or proven drugs currently available, the stepped up efforts are a desperate measure to stop a disease that has defied traditional means of containing it.

“There’s never been a big market for Ebola vaccines,” said Thomas W. Geisbert, an Ebola expert here at the University of Texas Medical Branch in Galveston, and one of the developers of the vaccine that worked so well in monkeys. “So big pharma, who are they going to sell it to?” Dr. Geisbert added: “It takes a crisis sometimes to get people talking. ‘Ok. We’ve got to do something here.' ”

Dr. James E. Crowe Jr., director of a vaccine research center at Vanderbilt University, said that academic researchers who develop a prototype drug or vaccine that works in animals often encountered a “biotech valley of death” in which no drug company would help them cross the finish line.

Up to that point, the research may have cost a few million dollars, but tests in humans and scaling up production can cost hundreds of millions, and bringing a new vaccine all the way to market typically costs $1 billion to $1.5 billion, Dr. Crowe said. “Who’s going to pay for that?” he asked.

“People invest in order to get money back,” Dr. Crowe added.

The Ebola vaccine on which Dr. Geisbert collaborated is made from another virus, V.S.V., for vesicular stomatitis virus, which causes a mouth disease in cattle but rarely infects people. It had already been used successfully in making other vaccines.

The researchers altered V.S.V. by removing one of its genes — rendering the virus harmless — and inserting a gene from Ebola. The transplanted gene forces V.S.V. to sprout Ebola proteins on its surface. The proteins cannot cause illness, but they provoke an immune response that in monkeys, considered a good surrogate for humans, fought off the disease.

The vaccine was actually produced, in Winnipeg by the Public Health Agency of Canada. The Canadian government patented it, and 800 to 1,000 vials of the vaccine were produced. In 2010, it licensed the vaccine, known as VSV-EBOV, to NewLink Genetics, in Ames, Iowa.

The Canadian government donated the existing vials to the World Health Organization, and safety tests of the vaccine in healthy volunteers have already begun.


Almost 10 years ago...
Ebola vaccine developed that works 100% on monkeys.
Shelved before human trials due to no money in it.

And look who developed and patented it...
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Message 1591007 - Posted: 23 Oct 2014, 22:36:58 UTC - in response to Message 1591000.  

Possible new case.

Doctor who treated Ebola patients is rushed to NYC hospital

The Big Apple may have its first case of Ebola.

A 33-year-old Doctors Without Borders physician who recently treated Ebola patients in Guinea was rushed in an ambulance with police escorts from his Harlem home to Bellevue Hospital on Thursday, sources said.

Craig Spencer was suffering from Ebola-like symptoms — a 103-degree fever and nausea, sources said.

He landed at JFK airport on Oct. 17 on a connecting flight from Brussels, a source said. Spencer’s temperature was 98.7 degrees upon arrival, the source added.

Girlfriend quarantined...

http://nypost.com/2014/10/23/nyc-may-have-its-first-ebola-case/
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Message 1591008 - Posted: 23 Oct 2014, 22:39:36 UTC - in response to Message 1591007.  

Possible new case.

Doctor who treated Ebola patients is rushed to NYC hospital

The Big Apple may have its first case of Ebola.

A 33-year-old Doctors Without Borders physician who recently treated Ebola patients in Guinea was rushed in an ambulance with police escorts from his Harlem home to Bellevue Hospital on Thursday, sources said.

Craig Spencer was suffering from Ebola-like symptoms — a 103-degree fever and nausea, sources said.

He landed at JFK airport on Oct. 17 on a connecting flight from Brussels, a source said. Spencer’s temperature was 98.7 degrees upon arrival, the source added.

Girlfriend quarantined...

http://nypost.com/2014/10/23/nyc-may-have-its-first-ebola-case/



I saw that about 3 hours ago... They should have the initial test results back on him in about 8 or 9 hours.

I must wonder, though, why they removed the door from his apartment building...
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Message boards : Politics : Ebola and Infectious diseases Part Two


 
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