I have a couple 650Ti cards due in next week, and have the time and ability to restart a system from scratch if needed.

Preference on OS? I have MSDN account so can install anything from XP to Server 2012 R2. Linux is on the table as well if is more efficient for the projects.
As it stands the 2 cards would go in this system http://setiathome.berkeley.edu/show_host_detail.php?hostid=7243183

I have a couple systems as a base to put the cards in.
Athlon II X4 630
Opteron 6128 (has x8 slots but shouldn't be an issue)

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In my test lab I use ghost images of various OS. Testing with various versions of Windows I didn't find any advantage when using one version over another. Normally I just run Windows 7 x64 on them when the machines are not needed for anything else.

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SETI@home classic workunits: 93,865 CPU time: 863,447 hours
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In my test lab I use ghost images of various OS. Testing with various versions of Windows I didn't find any advantage when using one version over another. Normally I just run Windows 7 x64 on them when the machines are not needed for anything else.

Are you able to test GPU apps with those ghost images? My GPU experience - limited to NVidia cards - suggested that XP is more efficient, because of the simpler driver model.

In my test lab I use ghost images of various OS. Testing with various versions of Windows I didn't find any advantage when using one version over another. Normally I just run Windows 7 x64 on them when the machines are not needed for anything else.

Are you able to test GPU apps with those ghost images? My GPU experience - limited to NVidia cards - suggested that XP is more efficient, because of the simpler driver model.

Other than an old 8500 GT I don't have any other GPU hardware to test.

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SETI@home classic workunits: 93,865 CPU time: 863,447 hours
Join the [url=http://tinyurl.com/8y46zvu]BP6/VP6 User Group[